In early 90's Ching Long, a young rebellious man who moved from Hong Kong to Taiwan against his father's wishes, and his best friend Ko Tin Chun,who is a successful young architect. Ching Long returns to Hong Kong working manual labour jobs and also as a stunt double. His family consists of his son, his father, and younger sister. The story revolves around Long and misunderstanding with his father as well as his romanticrelationships with a Vietnamnese refugee Chin Kiu and his sister's best friend, Sum Mun Yee. Ko Tin Chun is in love with Sum Mun Yee but he finds out that her heart is with Ching Long. Other events causes Ko Tin Chun to see Ching Long as an obstacle in his life. Jealousy grows in Ko Tin Chun's heart and he ends up marring Ching Long's sister as a plot against Ching Long. He is ruthless and even ends up committing murder to reach his goal.

四十集時裝劇「今生無悔」道盡了人的性格與命運的關係。在同一環境之內，會緞練出不同性格的人；而人的性格，卻往往影響他一生的遭遇和命運。有人但求目的不擇手段。結果弄至心力交疲；有人卻能緊執宗旨，依良心做事，終能扭轉乾坤，主宰命運。
劇中主角程朗（黎明）自小被父程孝全（劉兆銘）送往寄宿學校，養成反叛不羈性格，後更離家往台灣朗蕩去。朗妹程虹（楊美儀）見父兄不和，借邀朗回港參加畢業典禮為名，希望能一家團圓。
朗終回港與父修好，並巧遇童年好友建築師高天俊（溫兆倫），重拾舊日友誼。
朗於偶然機會結識滯港越南難民展翹（邵美琪），二人發展出一段刻骨銘心的愛情，惜最終以翹離港告終。朗失落之餘，得沈文薏（周海媚）扶持，重建信心，發展事業，二人情愫亦漸生。
而心高氣傲的高天俊亦鍾情於薏，眼看情人投向朗懷抱，對朗漸生懷恨之心。後更出賣兄長高天祿（許紹雄），以搏取富商白樹泰（關海山）的信任，撈取資本打擊程朗。一幕幕驚心動魄的鬥爭，一段段糾纏不清的戀情由始展開。

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