Nick Cheung, the newly-emerged comedian, is coupled with his real life lover, Esther Kwan, for the first and only time on TV. The sweet couple star alongside with two other famous comedy actors Bobby Au-Yeungand Lam Ka Tung, the handsome Marco Ngai, the beautiful and lovely actresses Yung Hung, Nnadia Chan and Man Chung Han. They all perform very well in their respective roles and contribute to the ultimate success of the drama. The lively theme song sung by the actors and actresses themselves also clearly reflects the style and tone of the drama. This high quality TVB millennium production, featuring some of the most popular artists in the era, comprising entertaining jokes, sweet romances, funny and appealing storylines, and above all, highlighting excellent performances from outstanding artists , is absolutely a drama which all viewers should not miss.

以唐伯虎（張家輝）、祝枝山（歐陽震華）、文徵明（林家棟）為首的江南隊，連續兩年在南北才藝奪錦大賽中勝出，三人樹大招風，惹來波斯奇才周文賓（魏俊傑）的挑戰，賓以卑鄙的手段擊敗三子，後卻被唐伯虎揭穿陰謀而身敗名裂，後幸得三子相救，四人結成八拜之交。四子上京赴考，終於取得功名，更被寧王聘為幕僚。文徵明和寧王之女朱娉婷（陳松伶)產生了感情，而周文賓也與祝枝山之妹祝曉蓮（文頌嫻）兩情相悅，祝枝山則與華太師府中的廚子石榴（翁虹）結成鬥氣冤家。唐伯虎為追查華太師府中的寶藏而混入其中，喬裝成書僮華安，與俏丫環秋香（關詠荷）互生情愫。在追查中，唐伯虎發現華太師（盧海鵬）忠心愛國，真正想謀反的是寧王，四子騎虎難下，只好佯狂避世，終日流連煙花之地。秋香發現艷妓秋月是自己失散多年的姐姐，但月被寧王所殺，她決意替姐姐報仇，不料卻行藏敗露，危在旦夕！寧王的奸計正逐漸進行，而四大才子是否能逃過成為亡國奴的命運？