Set in the 1920s, the story revolves around a female detective as she engages in crime solving during the Republican era.

香港開埠初期，首位華人爵士夫人祖迪費查，因丈夫失勢兼失蹤，落難到品流複雜的油麻地。有妓女被殺，犯案手法與英國連環殺手極相似，練目狄德英直指祖迪是疑兇！祖迪淪為階下囚，幸得曾是祖迪得力管家關一夫為她洗脫嫌疑。祖迪又重遇反目多年的親妹鮑妹娣、收養孤女丁曉堯，與魏素嘉、游池等街坊過着貼地市井生活。兇手再現，祖迪發揮「女福爾摩斯」頭腦徹查，發現謀殺案並不單純，丈夫與一夫均有可疑！兇手發出挑釁信，下個目標……

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