In the Ming Dynasty, Lord Yim Sai Fan (Law Lok Lam) kept professional assassins to get rid of those against him. As he considered Lord Yeung Kai Sing a thorn in his flesh, he sent his “Twelve Animals Killers” to wipe out the entire Yeung‘s family. However, since the Yeungs were good fighters, the “Twelve Animals Killers” failed to accomplish their mission. Fan, therefore, sent his last card, the “Man Killer” (Chin Siu Ho). The “Man Killer” had to complete the task before the night ended since he would regain his conscience in the day. When the “Man Killer” reached the Yeungs family, their finest fighter Ching (Cheung Siu Fai), who was Sing‘s son, were incidentally called away to attend a meeting, thus the whole family were slaughtered. However, just as the “Man Killer” killed Sing’s daughter-in-law, dawn broke. He was shocked by his own cruelty and was terribly ashamed. He decided to turn against Fan. Fan, therefore, had to exterminate him...

明朝奸相嚴嵩之子嚴世藩(羅樂林飾)為剷除異己楊繼盛，遂派出豢養的殺手「十三死肖」往楊家斬草除根。楊家乃武林世家，十二死肖接連失手，世藩最後派出最厲害死肖「人」甄兆人(錢小豪飾)執行任務。「人」擁有雙重人格，日間光明磊落，夜間冷酷無情，受了世藩的特殊訓練，武功出眾。適繼盛之子楊雲清(張兆飾)要赴武當，楊家慘遭滅門，當「人」手刃身懷六甲的楊家媳婦時，天剛正亮，此時「人」復現人性，良心發現痛不欲生，決背叛世藩流浪江湖。世藩恐「人」成後患，下令餘下死肖追殺之。「人」幸得雲清仗義相助，得以殲滅所有死肖，雲清更不記舊仇助「人」解除毒咒回復常態。「人」為報答雲清，決以死贖前罪。

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